Publications

Selected publications since 2004

  • Welsh DK, Yoo SH, Liu AC, Takahashi JS, Kay SA (2004) Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Current Biology 14: 2289-95 (PMID: 15620658; PMCID: PMC3777438)
  • Zhou J*, Liu CY* (co-first author), Back SH, Clark RL, Peisach D, Xu Z#, Kaufman RJ# (#co-senior author)(2006) The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Natl. Acad. Sci. USA. 103: 14343-8 (PMID: 16973740; PMCID: PMC1566190)
  • Liu AC*, Welsh DK* (co-first author), Ko CH, Tran HG, Zhang EE, Priest AA, Buhr ED, Singer O, Meeker K, Verma IM, Doyle FJ, Takahashi JS, Kay SA (2007) Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 129: 605-616 (PMID: 17482552; PMCID: PMC3749832)
  • Liu AC, Lewis WG, Kay SA (2007) Mammalian circadian signaling networks and therapeutic targets. Nature Chemical Biology 3 (10): 631-640 (PMID: 17876320)
  • Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA (2008) Redundant function of REV-ERB alpha and beta and non-essential role for BMAL1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genetics 4(2): e1000023 (PMID: 18454201; PMCID: PMC2265523)
  • Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. (2008) A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 beta. Proc Natl Acad Sci USA 105 (52): 20746–20751 (PMID: 19104043; PMCID: PMC2606900)
  • Mirsky HP,Liu AC, Welsh DK, Kay SA, and Doyle FJ. (2009) A model of the cell-autonomous mammalian circadian clock. Proc Natl Acad Sci USA 106: 11107-12 (PMID: 19549830; PMCID: PMC2699375)
  • Zhang EE*, Liu AC* (co-first author), Hirota T*, Miraglia LJ,Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW, Janes J, Su AI, Hogenesch JB# and Kay SA# (#co-senior author) (2009) A Genome-wide siRNA screen for modifiers of the circadian clock in human cells. Cell 139: 199-210 (PMCID: PMC2777987; PMID: 19765810)
  • Ko CH, Yamada YR, Welsh DK, Buhr ED, Liu AC, Zhang EE, Ralph MR, Kay SA, Forger D, Takahashi JS (2010) Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biology 8(10): e1000513 (PMID: 20967239; PMCID: PMC2953532)
  • Zhang EE*, Liu Y* (co-first author), Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy MR# and Kay SA# (#co-senior author) (2010) CRY mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nature Medicine 16: 1152-1156 (PMID: 20852621; PMCID: PMC2952072)
  • Ukai-Tadenuma M, Yamada R, Xu H, Ripperger JA, Liu AC and Ueda HR (2011) Delay in feedback repression by Cry1 is required for circadian clock function. Cell 144: 268-281 (PMID: 21236481)
  • Marpegan L, Swanstrom AE, Chung K, Simon T, Haydon PG, Khan SK, Liu AC, Herzog ED and Beaulé C (2011) Circadian regulation of ATP release in astrocytes. Journal of Neuroscience 31:8342-8350 (PMID: 21653839; PMCID: PMC3135876)
  • Ramanathan C, Khan SK, Kathale ND, Xu H, Liu AC (2012) Monitoring cell-autonomous circadian clock rhythms of gene expression using luciferase bioluminescence reporters. Journal of Visualized Experiments (67), e4234 3791/4234 (PMID: 23052244; PMCID: PMC3490247)
  • Khan SK, Xu H, Ukai-Tadenuma M, Burton B, Wang Y, Ueda HR and Liu AC (2012) Identification of cryptochrome differentiating domain required for feedback repression in circadian clock function. Journal of Biological Chemistry 287 (31): 25917-26 (PMID: 22692217; PMCID: PMC3406676)
  • Evans JA, Pan H, Liu AC, Welsh DK (2012) Cry1-/- circadian rhythmicity depends on SCN intercellular coupling. Journal of Biological Rhythms 27 (6): 443-452 (PMID: 23223370; PMCID: PMC3578226)
  • Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, and Sonenberg N (2013) Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79(4):712-24 (PMID: 23972597; PMCID: PMC3856944)
  • Anafi RC, Lee Y, Sato TK, Venkataraman A, Ramanathan C, Kavakli IH, Hughes ME, Baggs JE, Growe JP, Liu AC, Kim J and Hogenesch JB (2014) Machine learning helps identify CHRONO as a circadian clock component. PLoS Biology 12(4): e1001840 (PMID: 24737000; PMCID: PMC3988006)
  • Ramanathan C, Xu H, Khan SK, Shen Y, Gitis PJ, Welsh DK, Hogenesch JB, and Liu AC (2014) Cell type-specific functions of Period genes revealed by novel adipocyte and hepatocyte circadian clock models. PLoS Genetics 10(4): e1004244 (PMID: 24699442; PMCID: PMC3974647)
  • Kathale ND and Liu AC (2014) Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics (commentary). Proc Natl Acad Sci USA 111: 15869-70 (PMID: 25368193; PMCID: PMC4234540)
  • Cao R, Gkogkas CG, Zavalia ND, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S#and Sonenberg N# (#co-senior author) (2015). Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18(6):855-62 (PMID: 25915475; PMCID: PMC4446158)
  • Xu H*, Gustafson CL* (co-first author), Sammons PJ, Khan SK, Parsley NC, Ramanathan C, Lee HW, Liu AC# and Partch CL# (#co-senior author) (2015) Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus. Nature Structure Molecular Biology 22(6):476-84 (PMID: 25961797; PMCID: PMC4456216)
  • Xu L, Ruan G, Dai H, Liu AC, Penn J, McMahon DG (2016) Mammalian retinal Müller cells have circadian clock function. Molecular Vision 22:275-283 (PMID: 27081298; PMCID: PMC4812508)
  • Zheng Z, Kim H, Qiu, Y, Chen X, Mendez R, Dandekar A, Zhang X, Zhang C, Liu, AC, Yin L, Lin, J, Walker P, Kapatos G, Zhang K (2016) CREBH Couples Circadian Clock with Hepatic Lipid Metabolism. Diabetes 65(11): 3369-3383 (PMID: 27507854; PMCID: PMC5079639)
  • Gustafson CL, Parsley NC, Asimgil H, Lee H, Ahlbach C, Michael AK, Xu H, Williams OL, Davis TL, Liu AC, Partch CL (2017) A slow conformational switch in the BMAL1 transactivation domain modulates circadian rhythms. Molecular Cell 66: 447–457 (PMID: 28506462)
  • Hughes ME… Liu AC… Hogenesch JB (2017) Guidelines for genome-scale analysis of biological rhythms. Journal of Biol Rhythms 32(5):380-393 (PMID: 29098954) 
  • Ramanathan C, Liu AC (2018) Developing mammalian cellular clock models using firefly luciferase reporter. Methods in Molecular Biology 1755:49-64 (PMID: 29671262)
  • Wible RS*, Ramanathan C*, Sutter CH, Olesen KM, Kensler TW, Liu AC*, Sutter TR* (*equal contribution) (2018) NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus. eLife 7: e31656 (PMID: 29481323)
  • Delahaye LB, Bloomer RJ, Butawan MB, Wyman J, Hill JL, Lee HW, Liu AC, McAllan L, Han JC and van der Merwe M (2018) Time-restricted feeding of a high fat diet in C57BL/6 male mice reduces adiposity, but does not protect against increased systemic inflammation. Appl Physiol Nutr Metab. (in press) (PMID: 29717885)
  • Ramanathan C, Kathale ND, Liu D, Lee C, Freeman DA, Hogenesch JB, Cao R#, Liu AC# (#co-senior author) (2018) mTOR signaling regulates central and peripheral circadian clock function. PLoS Genetics 14(5): e1007369 (PMID: 29750810)